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For those practicing intermittent fasting , administration at the end of the fasting window, just before breaking the fast, provides a strong lipolytic signal during an already optimized metabolic state

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During the break, fat loss may slow but should not completely reverse if nutrition and activity levels remain consistent

When to Adjust Dosing Increase dose if: After 4-6 weeks at current dose, no measurable body composition changes occur, youre tolerating current dose without side effects, youre below the upper clinical range (1 mg daily), and your physician approves escalation based on comprehensive assessment